Chemonics is at the forefront of advancing the global human resources for health (HRH) agenda, leveraging expertise and research to develop fit-for-purpose and fit-to-practice health workforces that enhance health outcomes. Operating in over 20 countries, we facilitate increased local investment in HRH, bolster leadership and governance capacity, and enhance the performance and productivity of health workforces. Collaborating closely with local governments, PEPFAR, and the Global Fund for AIDS, Tuberculosis, and Malaria, we assess and optimize the roles of community-based workers in HIV service delivery and malaria prevention. Employing evidence-based strategies, we build partnerships, invest in health systems, and cultivate a culture of data use to address health system challenges. Through our person-centered, systems-thinking approach, we support stakeholders at all levels to equip frontline health providers and community health workers with the necessary skills, support, and resources. By refining the Health Worker Lifecycle Approach under the USAID flagship Human Resources for Health in 2030 (HRH2030) Program, we strengthen workforce capacity across all stages to ensure high-quality healthcare and achieve universal health coverage.