Malaria will be defeated. However, its elimination and eventual eradication will require developing multi-sector partnerships and responses, investing in innovative vector control products and tools, entomologic and case surveillance systems, and placing communities at the center of the design and scale-up of high impact interventions. We work with stakeholders at all levels of governance to build their ability to design, plan, and implement evidence-driven malaria control activities. In this way, these groups can mobilize target use of resources in areas of greatest need across sectors and build responsive malaria systems that maximize health and economic impact.