The end to tuberculosis (TB) is within reach. Achieving this goal requires holistic systems thinking so that we can address gaps in local health systems and underlying determinants of TB, including economic and social inequalities. We support actors from the community to national level to identify and address gaps in their health and community systems for integrated, patient-centered TB care and prevention, and we work across sectors to eliminate poverty and foster healthy societies. We are developing open-access laboratory network diagnostics tools to increase data visibility and evidence-based decision-making in countries with a high TB burden. Through our supply chain programming, we assist countries in their scale-up of TB prevention therapy. Through collaboration with National Tuberculosis Programs around the globe, we help governments increase private sector engagement in TB commodity supply chains to ensure they are reliable, cost-effective, and meet patient and community needs.