The threat of infectious diseases continues to rise: Changes in our climate are contributing to food insecurities, pushing populations to urban centers and increasing the potential for disease transmission. With these human-caused and naturally occurring changes, the breeding grounds for vectors of endemic and emerging diseases often are brought closer to vulnerable populations, amplifying the risk of pandemics. In addition, the threat of bioterrorism continues to pervade across the globe. In our increasingly interconnected world, preparing for and responding to public health emergencies require approaches that help countries strengthen their multidisciplinary ties and address coordination challenges among different sectors. We are working across the agriculture, environment, governance, food security, supply chain, information technology, and health sectors to help local actors prevent, detect, and respond to emerging health threats.